Lisinopril is an ACE inhibitor. ACE stands for angiotensin converting enzyme.
Usage
Lisinopril can be taken with or without food. Try to take it at the same time every day. It's common for people to take it in the morning. However, several studies report that nighttime dosing of blood pressure medications may provide better nocturnal and early morning blood pressure control, potentially reducing the risk of cardiovascular events (which are generally more common in the morning).
When taking Lisinopril 10 mg, it's generally recommended to take it with a full glass of water (about 8 ounces or 240 milliliters). Drinking enough water helps ensure the medication is properly absorbed and can also help prevent any potential stomach upset. Staying well-hydrated is important while taking any medication, as it aids in digestion and helps your body process and absorbs the medication efficiently.
lisinopril can start lowering blood pressure within an hour of taking the medication, with peak effectiveness within six hours of taking a single oral dose. However, it may take two to four weeks for your blood pressure to drop into the target range.
Drugs Interaction
Combining lisinopril with ibuprofen may reduce the effectiveness of lisinopril in lowering blood pressure. If you're taking both medications, it's essential to monitor your blood pressure closely.
lisinopril and ibuprofen medications can affect kidney function, especially when used together frequently or chronically. If you're also using a diuretic (a "water pill") or have preexisting kidney disease, you're at higher risk for impaired kidney function. Regular monitoring by your doctor is crucial.
Pharmacology
Mechanism of action
Competitive inhibitor of angiotensin-converting enzyme (ACE); prevents conversion of angiotensin I to angiotensin II, a potent vasoconstrictor; results in lower levels of angiotensin II which causes an increase in plasma renin activity and a reduction in aldosterone secretion; a CNS mechanism may also be involved in hypotensive effect as angiotensin II increases adrenergic outflow from CNS; vasoactive kallikreins may be decreased in conversion to active hormones by ACE inhibitors, thus reducing blood pressure
Half-Life Elimination
12 hours