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Cell death organizes tissues and eliminates extra and injured cells
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In apoptosis, caspases target specific proteins to disassemble the cell
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Procaspases are cleaved to form active heterodimeric caspases
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“Initiator” and “effector” caspases have long and short prodomains, respectively
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PS is exposed on dying cells
“Programmed” Cell Death or Apoptosis
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“Extrinsic” pathways - receptors and DED caspases
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“Intrinsic” pathways - cytochrome c and CARD caspases
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Bcl2 family proteins protect or promote cytochrome c release
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IAP family proteins inhibit caspases